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Table 3 Transcripts associated with detoxification function with significantly greater expression in (A) naive N. bryanti relative to experienced N. bryanti and (B.) experienced N. bryanti relative to naïve N. bryanti

From: Evidence for functional convergence in genes upregulated by herbivores ingesting plant secondary compounds

 

Gene ID

Gene description

Ratio

p-value

A.

Greater expression in naïve N. bryanti

  

Phase I - catalyze oxidation, reduction and hydrolysis reactions

  
 

Alcohol dehydrogenases - oxidize alcohols

 

NM_009626

C57BL/6 J alcohol dehydrogenase class 4

2.11

0.019591

 

Carboxylesterases - hydrolyze carboxylic acid esters

 

NM_145603

Carboxylesterase 2

2.52

0.001284

 

NM_145603

Carboxylesterase 2

2.52

0.001213

 

NM_021456

Carboxylesterase 1

2.45

0.036796

 

NM_021456

Carboxylesterase 1

2.36

0.040035

 

NM_172759

Carboxylesterase 5,

2.12

0.001463

 

Cytochromes P450 - oxidize wide range of organic substrates

 

NM_028191

Cytochrome P450, family 2, subfamily c, polypeptide 65

15.62

0.006602

 

NM_007825

Cytochrome P450, family 7, subfamily b, polypeptide 1

4.48

0.000458

 

XM_219933

PREDICTED: P450 family 2 subfamily c polypeptide 79, SimilarTo

4.43

0.001591

 

NM_028191

Cytochrome P450, family 2, subfamily c, polypeptide 65

3.79

0.009243

 

NM_007825

Cytochrome P450, family 7, subfamily b, polypeptide 1,

3.24

0.001260

 

NM_019138

Cytochrome P450, family 7, subfamily b, polypeptide 1

2.46

0.002067

 

NM_019138

Cytochrome P450, family 7, subfamily b, polypeptide 1

2.2

0.002338

 

NM_010009

25-hydroxyvitamin D3 1alpha-hydroxylase

2.12

0.021096

 

Flavin containing monooxygenases - oxidize amines

 

NM_018881

Flavin containing monooxygenase 2, mRNA

2.78

0.018212

 

NM_018881

Flavin containing monooxygenase 2, mRNA

2.66

0.026835

  

Phase II - catalyze transfer of conjugates to metabolites

  
 

Acetyltransferases - transfer acetyl conjugate

 

NM_001161712

Glycine C-acetyltransferase transcript variant 2 SimilarTo

3.45

0.015595

 

UDP glucuronosyltransferases - transfer glucuronic acid conjugate

 

NM_172881

UDP glucuronosyltransferase 2 family, polypeptide B35

3.93

0.048799

 

NM_153598

UDP glucuronosyltransferase 2 family, polypeptide B34

2.86

0.000686

 

NM_153598

UDP glucuronosyltransferase 2 family, polypeptide B34

2.6

0.000899

 

NM_001029867

UDP glucuronosyltransferase 2 family, polypeptide B36

2.02

0.000218

 

Glutathione S-transferases - transfer glutathione conjugate

 

NM_012577

Glutathione S-transferase pi

2.67

0.003827

 

Methyltransferases - transfer methyl group conjugate

 

NM_016785

Thiopurine methyltransferase

5.2

0.000140

 

NM_016785

Thiopurine methyltransferase

5.04

0.000190

 

NM_016785

Thiopurine methyltransferase

4.72

0.000223

 

NM_016785

Thiopurine methyltransferase

4.3

0.000073

 

NM_022884

Betaine-homocysteine methyltransferase 2

3.48

0.001257

 

NM_022884

Betaine-homocysteine methyltransferase 2

2.15

0.005312

 

NM_026440

RNA (guanine-7-) methyltransferase

2.12

0.004311

 

NM_022884

Betaine-homocysteine methyltransferase 2

2.11

0.005705

 

NM_177846

MKIAA0547 protein

2.04

0.000481

 

Sulfotransferases - tranfer sulfo group conjugate

 

NM_001184980

Sulfotransferase family 2A DHEA-preferring member 5, SimilarTo

4.75

0.006821

 

NM_001101586

Sulfotransferase family 2A DHEA-preferring member 5, SimilarTo

4.73

0.020208

 

NM_001101586

Sulfotransferase family 2A DHEA-preferring member 5, SimilarTo

4.69

0.025323

 

NM_001101534

CDNA clone IMAGE:9053718

4.11

0.031920

B.

Greater expression in experienced N. bryanti

  

Phase I - catalyze oxidation, reduction and hydrolysis reactions

  
 

Aldo-keto reductases - oxidize and reduce aldehydes and ketones

 

NM_013777

Aldo-keto reductase family 1, member C12

22.98

0.000139

 

NM_030611

Aldo-keto reductase family 1, member C6

7.65

0.000074

 

Aldehyde dehydrogenases - oxidize aldehydes

 

NM_153543

Aldehyde dehydrogenase 1 family, member L2

3.61

0.000215

 

NM_031057

Aldehyde dehydrogenase 6 family, member A1

2.19

0.046613

 

Carboxylesterases - hydrolyze carboxylic acid esters

 

NM_145603

Carboxylesterase 2

6.91

0.000264

 

NM_001190346

Carboxylesterase 2 transcript variant 2, SimilarTo

6.55

0.000143

 

NM_145603

Carboxylesterase 2

6.21

0.000575

 

NM_001044258

Similar to Carboxylesterase 2

6.04

0.000027

 

NM_001044258

Similar to Carboxylesterase 2

5.68

0.000028

 

NM_001190346

Carboxylesterase 2, transcript variant 2, SimilarTo

3.63

0.000532

 

NM_172759

Carboxylesterase 5

2.9

0.001251

 

Cytochromes P450 - oxidize wide range of organic substrates

 

NM_023025

Cytochrome P450, family 2, subfamily J, polypeptide 4

6.7

0.002710

 

NM_012730

Cytochrome P450, family 2, subfamily d, polypeptide 2

3.38

0.035947

 

NM_012730

Cytochrome P450, family 2, subfamily d, polypeptide 2

3.34

0.019677

 

NM_012730

Cytochrome P450, family 2, subfamily d, polypeptide 2

3.25

0.047435

 

NM_153312

Cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1

3.1

0.006788

 

NM_153312

Cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1

2.92

0.000334

 

NM_022434

Cytochrome P450, family 4, subfamily f, polypeptide 14

2.34

0.002319

 

Flavin containing monooxygenases - oxidize amines

 

NM_001161765

Flavin containing monooxygenase 5 transcript variant 1, SimilarTo

2.46

0.005855

 

NM_001161765

Flavin containing monooxygenase 5 transcript variant 1, SimilarTo

2.4

0.006221

 

Miscellaneous Phase I

 

NM_013626

Peptidylglycine alpha-amidating monooxygenase

2.23

0.005322

 

NM_001004086

Paraoxonase 3

2.18

0.000331

  

Phase II - catalyze transfer of conjugates to metabolites

  
 

Acetyltransferases - transfer acetyl conjugate

 

NM_053853

N-acetyltransferase 1

7.05

0.000017

 

NM_001108278

Spermidine/spermine N1-acetyltransferase family member 2

6.26

0.000021

 

NM_053853

N-acetyltransferase 1

5.39

0.000007

 

NM_053853

N-acetyltransferase 1

4.99

0.000010

 

NM_001006995

Acetyl-Coenzyme A acetyltransferase 2

3.73

0.004937

 

NM_001009657

Histone acetyltransferase 1

2.24

0.000395

 

NM_001009657

Histone acetyltransferase 1

2.04

0.000004

 

UDP glucuronosyltransferases - transfer glucuronic acid conjugate

 

NM_153598

UDP glucuronosyltransferase 2 family, polypeptide B34

11.7

0.000347

 

NM_153598

UDP glucuronosyltransferase 2 family, polypeptide B34

7.22

0.013582

 

NM_201642

UDP glucuronosyltransferase 1 family, polypeptide A6B

5.21

0.000008

 

NM_152811

UDP glucuronosyltransferase 2 family, polypeptide B1

3.37

0.043313

 

NM_153598

UDP glucuronosyltransferase 2 family, polypeptide B34

2.24

0.004634

 

NM_001191676

UDP glucuronosyltransferase 2 family polypeptide B34, SimilarTo

2.18

0.005383

 

NM_153598

UDP glucuronosyltransferase 2 family, polypeptide B34

2.06

0.007980

 

Glutathione S -transferases - transfer glutathione conjugate

 

NM_026672

Glutathione S-transferase, mu 7

10.47

0.038865

 

NM_026672

Glutathione S-transferase, mu 7

9.14

0.034704

 

NM_133994

Glutathione S-transferase, theta 3

8.12

0.003689

 

NM_133994

Glutathione S-transferase, theta 3

7.66

0.002784

 

NM_008183

Glutathione S-transferase, mu 2

4.77

0.000073

 

NM_008183

Glutathione S-transferase, mu 2

2.68

0.015619

 

NM_001024361

Similar to Glutathione S-transferase A1

2.54

0.040554

 

XM_001473911

PREDICTED: Glutathione S-transferase Mu 2, SimilarTo

2.41

0.000974

 

NM_001024304

Glutathione S-transferase mu 4

2.11

0.026064

 

NM_008183

Glutathione S-transferase, mu 2

2.09

0.001695

 

NM_001009920

Glutathione S-transferase Yc2 subunit

2.04

0.031287

 

Methyltransferases - transfer methyl group conjugate

 

NM_001008299

RNA (guanine-7-) methyltransferase

6.35

0.000009

 

NM_022884

Betaine-homocysteine methyltransferase 2

3.45

0.001721

 

NM_001106470

Similar to KIAA1627 protein

3.35

0.002862

 

NM_010321

Glycine N-methyltransferase

3.26

0.000333

 

NM_173765

Aminoadipate-semialdehyde dehydrogenase

3.02

0.000019

 

NM_010321

Glycine N-methyltransferase

2.84

0.000468

 

NM_027334

Methyltransferase like 7A

2.73

0.002067

  1. All animals were fed a creosote diet. Within populations, results are organized by major detoxification enzyme class. Duplicates indicate the response of multiple probes for a given gene.
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BMC Ecology

ISSN: 1472-6785

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