Ecto- and endoparasite induce similar chemical and brain neurogenomic responses in the honey bee (Apis mellifera)

Table 4 Functional analysis of genes regulated by Varroa parasitism

Biological process/ Molecular Function	P-value	# upregulated genes	# downregulated genes
Metallopeptidase activity	0.00193	5	4
Ascorbate and aldarate metabolism	0.0106	4	0
GPCR, family 3, C-terminal	0.0126	0	3
Metalloendopeptidase activity	0.0127	2	4
Nucleophile	0.0150	2	3
Carbohydrate binding	0.0170	2	5
Integral/intrinsic to plasma membrane	0.0243	4	6
Glutamate receptor activity	0.0320	0	4
Pattern/ Polysaccharide binding	0.0331	1	4
Starch and sucrose metabolism	0.0338	3	1
Peptidase activity, acting on L-amino acid peptides	0.0379	10	5
Hydrolase	0.0431	20	16
Developmental growth	0.0471	3	3
Metalloprotease	0.0482	2	2

Gene ontology biological process and molecular function categories that were overrepresented in the brain transcriptomic profile are shown (P < 0.05).

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